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 Endocrine disrupting compounds (EDC) encompass a wide range of pollutants, including pharmaceuticals and personal care products (PPCP), pesticides, and steroids to name a few. EDC are thought to disrupt the endocrine function of mammals and fish, and as a result their biological effects are a growing concern. In order to properly assess the effects of these compounds on our environment, it is necessary to accurately monitor their presence. LC/MS/MS analysis is a highly feasible approach for the monitoring of a large set of endocrine disrupting compounds spanning multiple categories and chemical classes. MRM mode allows for the determination of these compounds in river water matrix with low detection limits and high selectivity. Confirmation was achieved by the simultaneous monitoring of a second MRM transition and calculation of the corresponding ion ratio. LC/MS/MS is a straight forward approach for the analysis and confirmation of these compounds with excellent sensitivity and ruggedness. Application Note: Analysis of Endocrine Disruptors, Pharmaceuticals, and Personal Care Products in River Water  Eight EDC and PPCP compounds were detected in the Influent and Effluent of River 1. Despite the rural nature of this location, low level of these widely used herbicides and pharmaceuticals are still detected. As expected a larger list of compounds were detected in the River 2 samples because of it urban origin. In total 23 EDC and PPCP compounds were founds at low to mid part per trillion (ppt) levels. These results show that it is possible to scan for a functionally diverse set of compounds in one analysis and achieve high sensitivity and accurate quantitation. A number of river water sample were extracted and analyzed for the presence of EDC and PPCP. |
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